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In humans, many circadian-regulated rhythms exhibit attenuated amplitude and phase shifts in older age (Figure 2 illustrates schematically some documented changes: rhythms of locomotor activity (rest-activity cycle), core body temperature, hormone secretion (e.g., melatonin at night, cortisol in the morning), SCN neuronal firing rate, and even daily metabolic indicators like plasma glucose all show diminished oscillation amplitudes in older adults compared to younger adults

doi:10.1080/09513590.2019.1640673 Fruzzetti F, Benelli E, Fidecicchi T, Tonacchera M

Given that neurological disorders, including PACS, exhibit a range of puzzling biochemical changes and diverse symptoms, there is significant interest in uncovering the key drivers behind these conditions and their parallels

Metabolic Signaling Influence IGF-1 LR3 is investigated for its interaction with metabolic signaling networks, influencing glucose uptake and nutrient utilization at the cellular level

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