Protects from free radicals: Antioxidants like glutathione reduce oxidative damage
NAD+ has no known effect on edema and doesn't interact with this mechanism
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Notably, animal models have demonstrated that transferring dysbiotic microbiota from CFS/ME patients to germ-free mice can induce fatigue-like behaviors, supporting a causal role for the microbiome in disease pathogenesis ( 3.5.4 Gut microbiota-based therapeutic interventions 3.5.4.1 Probiotics Given these findings, probiotic supplementation, particularly with strains of Lactobacillus and Bifidobacterium , has shown potential to restore microbial balance, enhance SCFA production, and reduce inflammation in CFS/ME patients (Skjevling et al., 2024)
Reduced reactive oxygen species (ROS): Stabilizing the electron transport chain limits electron leak, which in turn reduces superoxide and other damaging ROS without broadly interfering with normal redox activity
