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In contrast, small molecules internalize the epithelium via the paracellular pathway through intercellular tight junctions (Ozsoy et al., 2009)

Thus pre-treatment with L-arginine counteracted the antidepressant-like effect of imipramine, venlafaxine and bupropion (Krass et al., 2011), while inhibition of nitric oxide levels within the hippocampus can induce antidepressant like effects (Joca and Guimaracs, 2006)

The other pharmacological approaches for targeting 7nAChR include drugs promising to have therapeutic effects through 7nAChR, which are not essential to be agonists

(2011) 94:1776s84s