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Contributing factors may include female age, anatomical and chromosomal irregularities, genetic predispositions, endocrinological issues, placental abnormalities, infections, lifestyle choices such as smoking and alcohol use, psychological influences, and exposure to environmental hazards like heavy metals, pollution, and radiation ( Despite ongoing research, the underlying causes of RM remain elusive, hindering effective treatment options and adding to the emotional burden on patients

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Elevated levels of CRP and MPO frequently co-occur with pro-inflammatory cytokines tumor necrosis factor- (TNF-) and interleukin-6 (IL-6) in experimental diabetic neuropathy models 26,8991 (animal model, in vitro data)

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278,279,280,281 All above indicate that targeting Wnt signalling is an attractive strategy for the treatment of multiple diseases