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Sep 2018;39(8):1037-1044

It is currently classified as a research compound and is not approved for therapeutic use in humans in the United States

10.1089/ars.2013.5304 21 GiovinazzoD.BursacB.SbodioJ

For example, renal endothelial cells (critical for maintaining microvascular integrity) or mesangial cells may also undergo ferroptosis in response to contrast agents, yet their role in amplifying CIN injury (e.g., via paracrine signaling or microvascular rarefaction) has not been rigorously characterized

Moreover, petrelintide emphasizes molecular stability, neutral-pH formulation, and a potentially favorable balance between effectiveness and side-effect profile