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It blocks the interaction between keratinocytes and melanocytes, reducing the signal that tells melanocytes to produce pigment

In several murine transplantable models of cancer, MDSC were found to be the predominant source of prokineticin-2 (Bv8), a secreted protein involved in tissue-specific angiogenesis, which promoted vessel formation and tumor growth (87)

Furthermore, patients with LRRK2 gene mutations have reduced activity of complex I in vivo [102], and Lrrk2 in mice protects complex I from inhibitors such as MPP + [101]

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Cytometry 40(1):19-25, 2000