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Moreover, many of the early studies linking AIFM2 to apoptosis relied on predictive models, lacked apoptosis-specific markers or failed to demonstrate functional rescue using apoptosis inhibitors
Similar mechanisms may be responsible for the enhanced vasodilatory action of peroxynitrite (ONOO) in the presence of GSH: peroxynitrite reacts with GSH to form S-nitrosothiols (RSNOs), which subsequently release NO over a prolonged period of time, thus extending NO's half-life and, as a result, relaxing vascular tone (25)
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