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Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes

This was corroborated by experiments on HK-2 cells exposed to high glucose conditions, confirming that WJ-39s tubular protection is closely tied to enhanced mitophagy via PINK1/Parkin signalling pathway ( 2.5 Increase in mitochondria-derived ROS and oxidative stress in DN Oxidative stress (OS) is a metabolic dysfunction mediated by an imbalance between the overexpression of reactive oxygen species (ROS) and the bodys antioxidant defence system ( 2 - ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radicals (OH )

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Forty two studies were included in the review (41 that met the inclusion criteria plus the French study)