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Hartmann, S., Kyewski, B., Sonnenburg, B

J Cardiovasc Pharmacol 41:880889 Kobayashi A, Kang M-I, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, Yamamoto M (2004) Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

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Upon forming the CRL5 complex, it is hypothesized to ubiquitinate and degrade negative regulators of matrix metalloproteinases (MMP2/9), thereby enhancing their secretion and subsequently promoting cell migration and invasion

Integrating transcriptomic, proteomic, metabolomic, and clinical data to construct network models will reveal how SQOR interacts with other pathways and influences disease progression across pathological states