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In the presence of VEGF, MDSCs can create a pro-angiogenic milieu within the tumors by secreting angiogenic factors including CCL2, CXCL8, CXCL2, IL-1, ANGPT1, ANGPT2, and GM-CSF [251, 252]

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Tirzepatide should be avoided by anyone pregnant or planning pregnancy, and its use always belongs under a qualified clinicians supervision

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