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Retatrutide improves insulin sensitivity through GLP-1 and GIP pathways, while growth hormone can transiently increase insulin resistance

Therefore, the System Xc GSHGPX4 axis constitutes a complete and finely tuned antioxidant defense chain ( via genetic knockout in various cell types, or directly targeting its active site with small molecule inhibitors like RSL3, consistently and efficiently induces typical ferroptosis ( in vitro and in vivo evidences collectively establish the indispensable physiological protective role of GPX4 in maintaining organismal redox homeostasis and defending against ferroptosis ( 2.3 Experimental evidence for ferroptosis in OA In recent years, as our understanding of ferroptosis has deepened, numerous basic and preclinical studies have accumulated compelling evidence supporting its active role in OA pathology

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