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Description

To examine AP1 promoter activity following copper-induced upregulation of FOS , FOSB , JUN , and JUNB , a luciferase reporter assay was performed in HepG2 and HepG2 ATP7B-KO cells

PLoS ONE 7 , e46803 (2012)

et al., 2019)

10.1074/jbc.C100273200 J

There is no evidence that doses above 500mcg produce proportionally better results, and clinical trials using 1mg daily did not dramatically outperform lower doses