The immune tolerant phase evolves under immune pressure into the HBeAg-positive chronic hepatitis B phase, characterized by increased ALT levels, persistence of HBeAg, and more than 104 IU/mL of HBV DNA
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Studies show that when used appropriately, theyre a safe and effective way to restore healthy B12 levels
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This relatively low level of protection, however, was sufficient to qualify one of these vaccines for clinical development and human testing [24]