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The pineal gland serves as the bodys primary source of melatonin, a hormone that regulates sleep-wake cycles and exhibits various biological functions

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This is one mechanistic reason IV and parenteral administration have shown some tissue-level effects in animal studies

10-O-(N, N-dimethylaminoethyl) ginkgolide B methanesulfonate (XQ-1H) has been shown to normalize the expression of claudin-5, occludin, ZO-1, and -catenin in ischemic stroke model mice, leading to reduced BBB permeability and protection against oxygenglucose deprivation/reoxygenation injuries [292]