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Milk thistle may also interact with the following medications, though the interactions are less concerning and only require monitoring after ingestion:2 Fosphenytoin-phenytoin Indinavir Losartan Metronidazole Sirolimus Tolbutamide Vitamin K antagonists On the brighter side, most adverse reactions to milk thistle are minor and brief

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For example, B12 injections are typically administered every 1-4 weeks based on individual needs

Then, in phase two of detoxification, glutathione is required again as a chaperone to attach to various toxic substances and render them inactive, also making them water-soluble and more easily transported out of the body