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This evidence base reveals a significant translational gap between extensive animal research and limited clinical validation in human subjects

People of thiamin deficiency include those affected by: pregnancy chronic illness inadequate dietary intake alcoholism bariatric surgery chronic diuretic therapy Prolonged, untreated thiamin deficiency may lead to Wernicke-Korsakoff syndrome, a disorder that can affect people with chronic alcoholism, gastrointestinal disorders, or AIDS

Tapper EB, Lok AS

Abstract Purpose The prevalence of follow-on and compounded products of glucagon-like peptide-1 analogs is increasing