Three main short-chain fatty acids inhibit the activation of THP-1 cells by Mycoplasma pneumoniae
CHAC1 is involved in the stress-induced apoptosis of -cells, contributing to the progression of both type 1 and type 2 diabetes by impairing insulin production ( In muscle-wasting conditions like cancer cachexia, CHAC1 exacerbates oxidative stress by degrading GSH, thereby accelerating muscle degradation and protein breakdown ( In respiratory diseases, such as bleomycin-induced lung injury and bronchopulmonary dysplasia, CHAC1 contributes to the resolution of inflammation by promoting the apoptosis of immune cells, but its role in oxidative stress also highlights its damaging potential (Figure 8) (Figure 9) ( FIGURE 8 FIGURE 9 CHAC1s role in acute liver injury and atherosclerosis further underscores its involvement in inflammatory and apoptotic pathways
The percentage of cells containing SG was quantified (n = 5 randomly selected fields of view)
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Annals of the New York Academy of Sciences (2010) 9
