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[25] Supplementation with vitamin B 12 during conditions of deficiency restores the intracellular level of cobalamin and maintains a sufficient level of the two active coenzymes: methylcobalamin and adenosylcobalamin
Elevated ROS levels or reduced antioxidant defenses lead to oxidative stress which results in damage to biomolecules such as proteins, lipids, carbohydrates, and nucleic acids [65, 66]
A longitudinal study characterising a large adult primary ciliary dyskinesia population
This is why Walshs approach emphasizes balancing methylationnot with folates, which can worsen symptoms in undermethylated individualsbut with nutrients that rebuild the methyl cycle naturally
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