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Many people dont consume enough Vitamin B12 in their diet and therefore experience a vitamin B12 deficiency, those who follow a vegetarian and vegan diet for example

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CNS disorders with widespread iron accumulation in areas, including the basal ganglia, might not fully benefit if the drug mainly targets certain areas

While acute cuprizone intoxication in rodents has shown to lead to increased synaptic density in superficial cortical layers, in the subcortical area, such as the dorsal lateral geniculate nucleus, the contrary has been observed

Fish: Sardines, salmon, and other fish are excellent sources of B12