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Therefore, the RNA transport function of extracellular vesicles in sperm plays an important role in establishing sperm epigenome, which then affects embryonic development and ultimately leads to the transgenerational transmission of epigenetic effects by environmental effects ( 3.4.4 EVs have potential value in the diagnosis and treatment of asthenozoospermia EVs can serve as biomarkers for AS diagnosis

Modulates nitric oxide pathways, improving blood flow and nutrient delivery

PMID: 35459628

The PMRS transfers electrons from the intracellular cytosolic RBC compartment to the extracellular medium by oxidizing intracellular electron donors like ascorbate and NADH, acting as a compensatory mechanism against elevated ROS/OS, and may contribute to redox regulation throughout the body [42]

They are sometimes referenced together in informal 'Wolverine stack' planning