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This pathway allowed AOD-9604 to be marketed in the United States as a dietary supplement without the efficacy evidence required for a New Drug Application (NDA)

The high NAD+ base carries a concentrated MOTS-c and 5-Amino-1MQ pairing, making it primarily a concentrated MOTS-c / 5-Amino-1MQ blend on an NAD+ foundation

With IV Vitamin B12 therapy, the nutrient is delivered directly into your bloodstream, enabling immediate uptake

When 5-Amino-1MQ inhibits NNMT, nicotinamide is preserved and available for NAD+ synthesis, leading to increased intracellular NAD+ concentrations

This translates to a relative reduction in liver fat by 37%, indicating a possible benefit in lowering liver fat accumulation