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Microbiota-Gut-Brain Axis and the Central Nervous System

Cell Death & Differentiation , 25 (3), 486541

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At the synaptic level, SIRT1 influences learning by modulating CREB-regulated transcription co-activators, enhancing BDNF expression, shaping dendritic spine maturation, and regulating long-term potentiation

For example, one recent study reported that 87% of ASD children had side effects with risperidone, including drowsiness, weight gain, and rhinorrhea (8)