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Inhibitors with -phenyl-,-unsaturated carbonyl functionality Recently, it was reported that benzylidenehydantoin 18a , benzylidenepyrrolidinedione 18b , and benzylidenethiazolidine-2,4-dione 18c (Figure 8(a)) derivatives as potential tyrosinase inhibitors and using in vivo studies the compounds were proved to be an effective skin whitening agents 7780

Stacking them targets both sides of the energy balance equation simultaneously, which is why the combination generates interest

It upregulates growth factor receptors (VEGFR2, FGFR2) and accelerates extracellular matrix remodeling in animal wound models