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H3K9 crotonylation (H3K9cr), H3K9 acetylation (H3K9ac) and H3K18la dynamically change in the genome during embryonic development, working together with other PTM modifications to determine chromatin accessibility and neuronal fate [54]

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Leaky gut and autoimmune diseases

Even though the 3D structure of OCTN2 is still not known, the molecular determinants for substrate specificity have been revealed: one ammonium and one carboxylate groups are strictly required for transport, while the distance between them is not important (Figure 2)

Both pathways help maintain intracellular Cys levels