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Tirzepatide receptor pharmacology and predicted receptor occupancy GIPR-forward dual-incretin design, cAMP-biased GLP-1R with low beta-arrestin, GCGR negative control (EC50 329 nM)

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Der entscheidende Unterschied ist klassenbedingt: Cagrilintide ist ein Amylin-Analogon (eigener Sttigungs-Signalweg) und kein Inkretin-Agonist deshalb wird es hufig mit GLP-1 kombiniert und nicht als Alternative gegenbergestellt

Brief temperature excursions (a few hours at room temperature) typically cause minimal potency loss