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Studies show plasma GHK-Cu decreases with age, from approximately 200 ng/ml at 20 to approximately 80 ng/ml at 60

The absence of reported adverse effects in short-duration animal studies is not equivalent to confirmed long-term safety

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Visible improvements in coverage and thickness develop over 3 to 6 months as hair cycles shift

Critically, AOD-9604 did not produce the metabolic side effects associated with full-length growth hormone, including no insulin resistance or glucose intolerance, no elevation of IGF-1 levels, no fluid retention or joint pain, and no cardiovascular parameter changes