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In addition, Anti-apoptotic effect of silymarin against UV irradiation has been revealed by up-regulation of tumor-suppressor genes p53- and p21CIP1 (4,36)

Specifically, research by Lall et al

Preclinical models demonstrate that these compounds reduce reactive oxygen species, stabilize mitochondrial membrane potential, enhance mitophagy, and activate NRF2 dependent transcription, which translates into attenuation of ASD like behaviors in VPA, propionic acid, maternal immune activation, and BTBR paradigms (Bambini Junior et al., 2014

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10.1002/glia.23152 Glia 112 SarkakiA.FarboodY.DolatshahiM.MansouriS