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a homologous sequence-conservation screen against all possible transcripts that were independent of and not derived from angiotensinogen looking for similarities to AngIV identified partial homology with the hinge region (Yamamoto et al., 2010) of the plasminogen family of proteins, which include plasminogen itself, its anti-angiogenic degradation product, angiostatin, and the protein hormones heptocyte growth factor (HGF) and macrophage stimulating protein (MSP)

Nakae et al., 2003

Curr Drug Targets

Reports of short-term tolerance exist in small observational settings, yet these reports lack randomized control, large populations, and multi-year follow-up

The team set out to design an enzyme to selectively degrade immunogenic gluten-derived peptides in the stomach