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References: Cleveland Clinic

Key Mechanisms That Influence Dosing Angiogenesis and Vascular Repair: BPC-157 promotes new capillary formation at injury sites, enhancing oxygen and nutrient delivery

In human brain microvascular endothelial cells, downregulating hypoxia-inducible factor-1 activity and inhibiting its downstream gene vascular endothelial growth factor ameliorates the increased paracellular permeability and the alterations of distribution pattern of occludin and zonula occludens-1 induced by high glucose level [75]