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The high levels of GSH, associated with the downregulation of GSS and increased G6PD expression, which is the main source of NADPH, is an indicator of a switch from GSH synthesis to glutathione recycling

Warners MJ, Vlieg-Boerstra BJ, Verheij J, van Rhijn BD, Van Ampting MT, Harthoorn LF et al

Symptoms recur as the disease flares

Furthermore, glucose-6-phosphate derived from glycolysis can be diverted into branching metabolic pathways, such as the pentose phosphate pathway (PPP), where it is partially oxidized to generate NADPH (28)

While it was originally studied for human use, its now being explored in veterinary medicine for its regenerative properties in dogs