NHS approach to B12 deficiency: NICE Clinical Knowledge Summaries recommend investigating B12 deficiency in patients presenting with macrocytic anaemia, unexplained neurological symptoms, or risk factors including pernicious anaemia, gastrectomy, malabsorption disorders, metformin use, proton pump inhibitors, or nitrous oxide exposure
It is at the vanguard of prospective therapeutic treatments for treating metabolic diseases, obesity, and possibly even the cellular mechanisms involved in aging because of its ability to block the enzyme Nicotinamide N-methyltransferase (NNMT)
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Results vary by model, dose, and tissue type, and they do not predict human outcomes