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Additionally, upregulated Ras-RAF-MEK pathway expression may enhance cancer cell sensitivity to ferroptosis by modulating VDAC2/3 function and increasing ROS generation (40)

Additional laboratory studies include negative results for hepatitis B and hepatitis C serologies, normal 1-antitrypsin genotype, transferrin saturation 39%, and serum ferritin 480 g/L

[2] [7] These effects typically diminish over time but can be pronounced during the initial weeks of treatment or following dose increases

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