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Current understanding relies heavily on extrapolation from consistent animal model results and accumulating anecdotal human reports

The barrier is characterized by an enrichment of interendothelial tight junction proteins, several luminal and abluminal transporters, and luminal efflux transporters, which together maintain separation of the blood and brain and tightly regulate molecular trafficking between the blood and brain and vice versa 20

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It also boosts immunity and anti-oxidative responses