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Role of gut-brain axis, gut microbial composition, and probiotic intervention in Alzheimer's disease

ROS-induced NO inactivation can impair vascular endothelial function, contributing to various pathologies like atherosclerosis, hypertension, cardiovascular disease, and central nervous system disorders (27, 28)

The analysis of the plasma in this cohort revealed a significant decrease in the SOD activity in active CD as compared to inactive CD (P = 0.0029) and the control group (P = 0.034)

Noticeably, Tau exhibits an anti-EAA toxicity effect (Wu and Prentice, 2010) by reducing neuronal excitability through the activation of -aminobutyric acid type A receptors (GABA A R), increasing Cl influx, and hyperpolarizing the cell membrane (Wang G

Instead, it works directly within fat cells to promote healthier metabolism