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[10] Enzyme-inducing anticonvulsants such as phenytoin, carbamazepine, and phenobarbital, as well as rifampicin, accelerate hepatic catabolism of vitamin D, shortening its half-life and potentially necessitating more frequent or higher intramuscular doses to sustain target 25-hydroxyvitamin D levels

[DOI] [PubMed] [Google Scholar] 155.Marcus R

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It also modulates extracellular matrix turnover by restoring the balance between metalloproteinases (MMPs) and their tissue inhibitors (TIMPs)

Another strategy involved the use of SIRT activator SRT1720 and the PARP inhibitor Olaparib, which enhanced SIRT1 activity and increased NAD + 111