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Web of Science, PubMed, and Cochrane Library from September 2018 to June 2020 were systematically searched by two investigators, and the published date for searched papers from the databases ranged from June 1990 to June 2020

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The abnormal release of Ca 2+ from the mitochondria to the cytosol leads to the activation of microglia, neuroinflammation, and finally, cell death [29, 93]