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we have observed the same phenomenon with regard to desensitization of another metabotropic glutamate receptor, mGluR2 (S Lennon, PJ Roberts and E Kelly, unpublished observations)

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10.1111/j.1365-2982.2010.01664.x 94 CuiL.LiS.WangS.WuX.LiuY.YuW.et al

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However, this metabolic adaptation also places greater stress on the ETC, further exacerbating ROS production (40)

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