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The follicle is embedded within an extracellular matrix (ECM) a complex scaffolding of proteins including collagen, laminin, and fibronectin that provides structural support, facilitates cellular communication, and delivers biochemical signals essential to follicular function

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First, cytoskeletal remodeling supports neurite outgrowth and neuronal survival , and T4 has been shown to promote these by upregulating the cell-adhesion molecule L1

LL-37 possesses immunomodulatory properties that influence various immune cells, including neutrophils, macrophages, dendritic cells, and lymphocytes (Nagaoka et al., 2001)