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They state There is a 30% of GI side effects some side effects will diminish over time as people get used to their doses STUDY 3 80,000 patients in Mayo Clinic 839 patients with gastroparesis Of these, 241 had food in their stomach four hours after eating a test meal More likely to be seen in women and those with constipation They state that the risk was not seen in the original studies as you need hundreds of thousands of patients to see these small numbers

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Ouellette J, Toussay X, Comin CH, Costa LDF, Ho M, Lacalle-Aurioles M et al (2020) Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice