Drenning JA, Lira VA, Soltow QA, Canon CN, Valera LM, Brown DL, Criswell DS
Nov 2015;31(11):1951-62
In challenge infections using WT UTI89 and UTI89 hlyA strains in nave, resolved and sensitized mice, we observed that hlyA infection, which does not activate caspase-1-mediated pyroptotic cell death, showed significantly increased bacterial burdens in sensitized mice compared with WT mice, whereas no differences were observed in nave and resolved mice (Fig
Both MRP1 and MRP3 function as organic anion transporters and prevent the entry of glutathione/glucuronide metabolites into the fetus since they assist in their excretion [89,90]
in vitro biological matrices for ADCs stability in WuXi AppTec DMPK Conclusion With the development and the accumulation of experience of antibody-drug conjugates, linker has been regarded as a crucial element in the ADC design