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Not only that, the IDoi@TBC-Hf nanoparticles formed by loading the IDO inhibitor (IDoi) indoleamine 2,3-dioxygenase into TBC-Hf (a new nMOF) using the highly porous structure of the nanometal-organic framework (nMOF) can reverse the inhibitory tumor microenvironment by releasing IDoi after local injection, and combined with PDT can induce ICD and further stimulate the immune system, leading to infiltration of CD4 + T and CD8 + T cells in the TME and effectively controlling both local and distant tumors (188)

2021) using gene sets from KEGG (Kanehisa, Sato, and Kawashima 2022) and MSigDb (Liberzon et al

This modified synthetic form is more potent and stable than the natural peptide

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Furthermore, Figures 5B, C suggest that RGD-GHK evidently suppressed the protein and mRNA level of matrix metalloproteinase-1 (MMP-1) in vitro , which catalyzes the cleavage of collagen