A deficiency can occur for several reasons, such as pernicious anemia (a condition where the body cannot absorb vitamin B12 from the diet), certain medical conditions (e.g., Crohn's disease, celiac disease), surgical removal of part of the stomach or intestine, or strict vegetarian/vegan diets if not adequately supplemented
5 mg (first therapeutic dose): This is where sleep disruption most commonly begins
It has shown promise in inflammatory bowel conditions and broader immune modulation
They do tap into the GABAergic pathway, neurotransmitter folks, that, in general, broad sweeping generalization here, can have somewhat of a sedative quality, which is why I take magnesium threonate and/or bisglycinate before sleep, 30 to 60 minutes before sleep
doi: 10.3390/cancers16010039