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For EPR-based tumor targeting, various drug delivery systems, such as liposomes, micelles, and polymer conjugates, are frequently used, with their sizes generally falling between 5 and 200 nm

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Zhou, Z., et al

M2-type macrophages exert synergistic effects in reducing inflammatory responses, promoting tissue repair, enhancing immune suppression, and supporting tumor growth by secreting anti-inflammatory cytokines (IL-10 and TGF-) and highly expressing arginase-1 (Arg1) (52)

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