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We require more high-quality large-scale human studies to support these advantages

BRIEF DESCRIPTION OF THE DRAWINGS Figure 1A, B, and C

Users pleasantly surprised by benefit retention during breaks can adopt cycling approach, while those experiencing concerning decline might choose resuming continuous use or maintenance frequency application

Primary antibodies were as following: ACTA2 (14395-1-AP, Proteintech), BCL2 (12789-1-AP, Proteintech), BAX (50599-2-lg, Proteintech), ICAM1 (10831-1-AP, Proteintech), TNF (17590-1-AP, Proteintech), IL6 (sc-28343, Santa Cruz), p-S6K (sc-8416, Santa Cruz), S6K (sc-8418, Santa Cruz), Tubulin (66031-1-Ig, Proteintech) and GAPDH (60004-1-lg, Proteintech)

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