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Nicotine is a substance that is widely present in the tobacco plant

But figuring out how to regulate e-cigarettes to maximize their benefits and minimize their risks is harder than it looks

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According to the Government Accountability Office (GAO), market shifts stemming from flawed tax design have resulted in between $2.5 billion and $3.9 billion in lost federal revenue between 2009 and 2018.[32] Fixing these problems or imposing moderate adjustments would solve problems while limiting risks of unintended consequences such as additional illicit trade and discouraging smokers from switching