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Vegans and vegetarians: Vitamin B12 is found naturally almost exclusively in animal products, making supplementation a consideration for those on plant-based diets

Mechanisms and outcomes Vitamin B12 interventions are commenced upon diagnosis of low B12 status, typically comprise high dose injections until levels are within acceptable range, and then the intervention is changed to a maintenance dose that is typically administered every 3 months ad infinitum

also observed with IV administration in humans as shown by an increase in inflammatory markers

Most practitioners check B12 levels at 3-6 months after initiating tirzepatide and then every 6-12 months during maintenance

Chai Y, Koppenhafer SL, Bonini NM, Paulson HL